Thrombocytopenia absent radius syndrome
Natural Standard Bottom Line Monograph, Copyright © 2009 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.
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Related Terms:
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Absent radius, congenital disorder, hypomegakaryocytic, Meckel's diverticulum, microcephaly, nuchal folds, petechiae, phocomelia, purpura, radial aplasia, radial aplasia-amegakaryocytic thrombocytopenia, radial aplasia-thrombocytopenia syndrome, radial club hand, TAR, TAR syndrome, tetraphocomelia-thrombocytopenia syndrome, thrombocytopenia, thrombocytopenia-absent radii syndrome, unilateral radial aplasia. |
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Thrombocytopenia absent radius (TAR) syndrome is a rare disorder that is congenital (present at birth). Thrombocytopenia is a general term for blood disorders that cause low levels of platelets. A platelet is a type of blood cell that helps the blood clot. These cells clump together at the site of a blood vessel injury in order to prevent blood loss. Therefore, thrombocytopenia is often associated with abnormal bleeding. TAR syndrome is characterized by very low levels of platelet-producing cells, called hypomegakaryocytic thrombocytopenia, associated with bilateral radial aplasia. This means that in addition to having dramatically low platelet levels, the bone that connects the elbow to the thumb side of the wrist (called the radius) fails to grow in both arms. |
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TAR syndrome was first defined as a syndrome in 1969. TAR can have varied symptoms, which can include abnormalities in the digestive, bone, blood, and heart systems. Despite the absence of the radius bones, TAR patients usually have both of their thumbs, although thumb function is very limited. |
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Bone defects are often present in individuals affected with TAR. In addition, TAR patients may be short for their age and are commonly intolerant of cow's milk. |
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Although TAR syndrome is not completely understood, it is generally believed to be inherited because it has affected more than one member of some families. However, further research is needed to confirm this genetic link. Evidence has suggested that TAR syndrome may be the result of a more complex inheritance pattern; other theories also exist. |
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Content available for subscribers only.
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Content available for subscribers only.
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Natural Standard Monograph
(www.naturalstandard.com)
Copyright © 2009 Natural Standard Inc. Commercial distribution or
reproduction prohibited.
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The information in this monograph is intended for informational purposes
only, and is meant to help users better understand health concerns.
Information is based on review of scientific research data, historical
practice patterns, and clinical experience. This information should not be
interpreted as specific medical advice. Users should consult with a
qualified healthcare provider for specific questions regarding therapies,
diagnosis and/or health conditions, prior to making therapeutic decisions.
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