Below is general information about the effectiveness of the known ingredients contained in the product ItchEase Herb Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product ItchEase Herb Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Angelica archangelica has Generally Recognized as Safe (GRAS) status in the US (4912). There is insufficient reliable information available about the safety of Angelica archangelica when used orally or topically for medicinal purposes.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately in medicinal amounts, short-term. An ashitaba extract has been used with apparent safety in doses of 500 mg twice daily for 12 weeks (100594). There is insufficient reliable information available about the safety of ashitaba when used long-term.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately. Dong quai has been used with apparent safety in a dose of 4.5 grams daily for 24 weeks, or in combination with other ingredients in doses of up to 150 mg daily for up to 6 months (19552,35797). ...when used intravenously as a 25% solution, in a dose of 200-250 mL daily for up to 20 days (48438,48442,48443,48483).
POSSIBLY UNSAFE ...when used orally in large amounts, long-term. Theoretically, long-term use of large amounts of dong quai could be harmful. Dong quai contains several constituents such as bergapten, safrole, and isosafrole that are considered carcinogenic (7162). There is insufficient reliable information available about the safety of dong quai when used topically.
PREGNANCY: POSSIBLY UNSAFE
when used orally.
Dong quai has uterine stimulant and relaxant effects (8142); theoretically, it could adversely affect pregnancy. Observational research has found that intake of An-Tai-Yin, an herbal combination product containing dong quai and parsley, during the first trimester is associated with an increased risk of congenital malformations of the musculoskeletal system, connective tissue, and eyes (15129).
LACTATION:
Insufficient reliable information available; avoid use.
There is insufficient reliable information available about the safety of mugwort when used orally or topically.
PREGNANCY: LIKELY UNSAFE
when used orally.
Mugwort is said to be an abortifacient and a menstrual and uterine stimulant (2,12).
LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when perilla oil or extract is used orally and appropriately. There is some evidence that perilla can be safely used for up to 12 months (1338,68676,94312,105525).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
There is insufficient reliable information available about the safety of self-heal.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when the leaf or essential oil is used orally in amounts commonly found in foods. Tarragon has Generally Recognized as Safe (GRAS) status in the US (4912). There is insufficient reliable information available about the safety of tarragon when used orally or topically in medicinal amounts, or when used by inhalation for aromatherapy.
PREGNANCY AND LACTATION: LIKELY UNSAFE
Insufficient reliable information is available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product ItchEase Herb Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A1 (100593). Theoretically, concomitant use of ashitaba with CYP1A1 substrates might decrease the clearance of these substrates and increase the risk for adverse effects. However, this interaction has yet to be reported in humans. Until more is known, use with caution.
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In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2 (100593). Theoretically, concomitant use of ashitaba with CYP1A2 substrates might decrease the clearance of these substrates and increase the risk for adverse effects. However, this interaction has yet to be reported in humans. Until more is known, use with caution.
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Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Details
Animal studies suggest that dong quai has antithrombin activity and inhibits platelet aggregation due to its coumarin components (6048,10057,96137). Additionally, some case reports in humans suggest that dong quai can increase the anticoagulant effects of warfarin (3526,6048,23310,48439). However, clinical research in healthy adults shows that taking 1 gram of dong quai root daily for 3 weeks does not significantly inhibit platelet aggregation or cause bleeding (96137). Until more is known, use dong quai with caution in patients taking antiplatelet/anticoagulant drugs.
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Theoretically, dong quai may reduce the effects of estrogens.
Details
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Dong quai may increase the risk of bleeding when used with warfarin.
Details
Case reports suggest that concomitant use of dong quai with warfarin can increase the anticoagulant effects of warfarin and increase the risk of bleeding (3526,6048,23310,48439). In one case, after 4 weeks of taking dong quai 565 mg once or twice daily, the international normalized ratio (INR) increased to 4.9. The INR normalized 4 weeks after discontinuation of dong quai (3526).
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Evidence from in vitro research suggests that tarragon extract inhibits platelet aggregation and adhesion (49445,76932,77038). Theoretically, tarragon might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
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Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneally at a dose of 1 mL/kg (77024). Theoretically, concomitant use of tarragon with CNS depressants, including antihistamines, barbiturates, benzodiazepines, and tricyclic antidepressants, may increase sedative and other adverse effects.
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In vitro research suggests that tarragon extract inhibits monoamine oxidase (MAO)-A and MAO-B enzymes (106774). Theoretically, concomitant use with MAOIs might increase the effects and adverse effects associated with MAOIs.
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Below is general information about the adverse effects of the known ingredients contained in the product ItchEase Herb Tea. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, Angelica archangelica is generally well tolerated in food amounts.
There is limited information available about the adverse effects of Angelica archangelica when used as medicine.
Most Common Adverse Effects:
Orally: Constipation, photosensitivity.
Dermatologic ...Orally or topically, Angelica archangelica might cause photosensitivity reactions (13406). Patients who take Angelica archangelica orally or apply it topically should be advised to avoid prolonged exposure to the sun. Some constituents of the leaves have a strong irritant effect on the skin and mucous membranes, referred to as "angelica dermatitis" (18).
Gastrointestinal ...Orally, Angelica archangelica has been reported to cause constipation in one out of 21 patients taking a specific Angelica archangelica leaf extract (SagaPro, SagaMedica) (92461).
General ...No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.
General
...Orally, dong quai is generally well-tolerated.
Most Common Adverse Effects:
Orally: Burping and flatulence.
Intravenously: Headache.
Cardiovascular ...Orally, dong quai might cause hypertension; according to one case report, a parent and breastfed infant experienced hypertension (195/85 mmHg and 115/69 mmHg, respectively) after the parent consumed a soup containing dong quai root (48428).
Dermatologic ...Dong quai contains psoralens that may cause photosensitivity and photodermatitis (10054,10057,48461).
Endocrine ...In a case report, a male developed gynecomastia after ingesting dong quai tablets (48504).
Gastrointestinal ...Orally, burping and gas may occur with dong quai (738).
Hematologic ...In one case report, a 55-year-old female with protein S deficiency and systemic lupus erythematosus (SLE) had temporary vision loss in the left eye from hemiretinal vein thrombosis three days after taking a phytoestrogen preparation containing dong quai 100 mg, black cohosh 250 mg, wild Mexican yam 276 mg, and red clover 250 mg (13155). It is unclear if dong quai contributed to this event.
Neurologic/CNS ...Dong quai given orally or by injection may be associated with headache (738,48438).
Oncologic ...Dong quai contains constituents that are carcinogenic; however, whether these constituents are present in concentrations large enough to cause cancer with long-term or high-dose use is unknown (7162).
Pulmonary/Respiratory ...A pharmacist experienced allergic asthma and rhinitis after occupational exposure to dong quai and other herbs (48435).
General
...Orally, adverse effects to mugwort seem to be rare; however, a thorough evaluation of safety outcomes has not been conducted.
Most Common Adverse Effects:
All ROAs: Allergic reactions.
Immunologic ...Allergy to mugwort pollen has been reported when taken orally or inhaled. Symptoms have included asthma, rhinitis, conjunctivitis, rash, and anaphylaxis (567,3717,31341,35623,57474,63909,63915,63917,92852,92853)(101049,101050,101051,101052).
Psychiatric ...Orally, mania has been reported in a 49-year-old male following the intake of 1 liter of an infusion thought to contain mugwort. The presence of thujone in the patient's serum and urine was confirmed, and thujone poisoning was considered to be the cause of these symptoms. Although thujone levels are normally low in mugwort, concentrations can be variable. It was postulated that the mugwort infusion contained an unusually high amount of thujone. It was also considered to be possible that the metabolism of thujone was decreased in this particular patient or that the poisoning was related to the chronic intake of small amounts. However, a sample of the plant was not analyzed, and adulteration or contamination by a related species cannot be ruled out (101053).
General
...Orally, perilla seems to be well tolerated.
Topically, there is currently a limited amount of information on the adverse effects of perilla.
Most Common Adverse Effects:
Topically: Dermatitis.
Serious Adverse Effects (Rare):
Orally: Anaphylaxis.
Dermatologic ...Topically, perilla may cause contact dermatitis (6,68664,94313).
Immunologic ...Orally, many cases of anaphylaxis have been reported in adults and children who consumed perilla seeds (94313,110611). Some research suggests that oleosin is the major constituent responsible for perilla allergies (110611).
Pulmonary/Respiratory ...Occupational asthma has been reported from breathing in smoke from roasted perilla seeds (94313).
General ...Orally, self-heal has been reported to cause nausea, vomiting, and diarrhea. Orally and topically, self-heal has been reported to cause allergic reactions in sensitive individuals (12).
Gastrointestinal ...Orally, self-heal has been reported to cause nausea, vomiting, and diarrhea (12). A combination product containing self-heal, Clematis mandshurica, and Chinese cucumber has been reported to cause epigastric pain, abdominal discomfort, nausea, reduced appetite, and dyspepsia. It is not clear if these effects are due to self-heal, the other ingredients, or the combination (101041).
Immunologic ...Orally and topically, self-heal has been reported to cause allergic reactions, including rashes and swelling of the throat, lips, and tongue, in sensitive individuals (12).
General ...No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted. There is concern that long-term consumption of estragole, a constituent of tarragon, increases the risk for cancer. However, this risk has only been shown in animals (77046,77029,77042).