Ingredients | Amount Per Serving |
---|---|
Quercetin Bioflavonoids extract
(20:1)
(Quercetin Bioflavonoids extract Note: 20:1 )
|
235 mg |
(Sophora japonica )
(buds)
|
4.7 Gram(s) |
Citrus Bioflavonoids extract
(from Citrus Fruits)
(Citrus Bioflavonoids extract (Form: from Citrus Fruits (Form: Citrus limon PlantPart: fruit rind, Citrus sinensis PlantPart: fruit rind Genus: Citrus Species: sinensis, Citrus paradisi PlantPart: fruit rind Genus: Citrus Species: paradisi, Citrus reticulata PlantPart: fruit rind Genus: Citrus Species: reticulata, Citrus aurantifolia PlantPart: fruit rind Genus: Citrus Species: aurantifolia)) )
|
235 mg |
(Pineapple)
(Bromelain (Form: Ananas comosus PlantPart: pineapple stem Genus: Ananas Species: comosus) Note: 1000 GDU/g )
|
45 mg |
(20:1)
(Rutin extract Note: 20:1 )
|
45 mg |
(Sophora japonica )
(buds)
|
900 mg |
Gelatin Capsule (Form: Gelatin, purified Water), Rice powder, Magnesium Stearate Note: vegetable grade, Silica
Below is general information about the effectiveness of the known ingredients contained in the product Quercetin. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Quercetin. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately. Doses up to 240 mg daily have been used safely for up to a year (6252,6253,10622,11457,18281,18284,91104,91105,91106,91111)(96449,103298). Higher doses up to 3200 mg daily have been used safely, short-term (18283,110546). ...when used topically and appropriately. Bromelain has been used safely as a debriding agent for up to 4 hours (18275,91113,103297,108148,108149).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when the fruit is used orally and appropriately. A specific brand of pagoda tree fruit extract (Rexflavone, Rexgene Biotech Co. Ltd.) has been used safely in doses of up to 350 mg daily for up to 12 weeks (99966).
POSSIBLY UNSAFE ...when the seeds are used orally (18). Regular use of seed meal can cause facial edema or even death (18).
PREGNANCY AND LACTATION: POSSIBLY UNSAFE
when the seed is used orally (18); avoid using.
There is insufficient reliable information available about the safety of the fruit when used orally during pregnancy or lactation.
LIKELY SAFE ...when used orally in amounts found in foods, such as fruits and vegetables.
POSSIBLY SAFE ...when used orally in medicinal amounts, short-term. Rutin has been used with apparent safety at doses of up to 600 mg daily for up to 12 weeks (6252,24560,91104,96766,105298). ...when applied topically as a cream (92236,99258,99260).
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts commonly found in foods.
There is insufficient reliable information available about the use of supplemental rutin; avoid amounts greater than those found in foods.
Below is general information about the interactions of the known ingredients contained in the product Quercetin. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Details
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen (14806). Bromelain is thought to have antiplatelet activity (10639,14806,18285,18286,37234). Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement (110547).
|
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Details
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg (14296).
|
Theoretically, pagoda tree might reduce the clearance of caffeine.
Details
Pagoda tree contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females (23582). This effect has been attributed to inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if this effect occurs with the lower amounts of genistein found in pagoda tree.
|
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Details
Animal research suggests that rutin has hypoglycemic effects (105299).
|
Below is general information about the adverse effects of the known ingredients contained in the product Quercetin. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, bromelain seems to be well tolerated.
Most Common Adverse Effects:
Orally: Diarrhea, flatulence, gastric upset, headache.
Topically: Pruritus, urticaria.
Dermatologic
...Topically, bromelain may cause dermal allergic reactions including urticaria, pruritus, and skin swelling (9184).
Redness, swelling, burning, pain at the application site, and cellulitis have also been reported rarely (108148,113513). In one case, a fixed drug eruption with pruritis near the groin was reported in a 33-year-old male taking bromelain 50 mg orally daily for 10 days. After discontinuation of bromelain and treatment with topical corticosteroid, the lesion resolved. Upon re-challenge with bromelain, the lesion reappeared in the same area (103300).
In another case report, a 61-year-old male with a history of chronic lower leg ulceration secondary to chronic venous hypertension and recurrent deep vein thrombosis on rivaroxaban presented with a deep-dermal burn on his lower calf. Bromelain-based topical enzymatic debridement agent Nexobrid 2 grams was applied to the burn site. Thirty minutes later, the patient experienced two instances of hemorrhage at the site of debridement. The patient was stabilized and treated with fluids, packed red cells, and tranexamic acid, and then the Nexobrid was removed (111656). Caution should be used in patients with underlying coagulopathies.
Gastrointestinal ...Orally, bromelain may cause gastrointestinal disturbances, including diarrhea, nausea, vomiting, flatulence, and abdominal pain (9184,18274,18282,96216,113513).
Immunologic
...Immunoglobulin E (IgE)-mediated allergic reactions to bromelain may occur (9184).
If inhaled, bromelain may cause sensitization and allergic reactions such as asthma (37199,37215,37233). In case reports of occupational inhalation of bromelain, additional allergic symptoms included difficulty swallowing, throat itching, eye irritation, and rhinitis (37214).
General
...Orally, pagoda tree flower and fruit seem to be well tolerated.
No adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted. The pagoda tree seed is possibly unsafe when consumed long-term.
Serious Adverse Effects (Rare):
Orally: With use of the seed, death and edema.
Other ...Orally, using pagoda tree seed long-term may cause edema and death (18).
General ...Orally, rutin is generally well tolerated.
Dermatologic ...Orally, rutin may cause flushing and rashes in some people (313).
Gastrointestinal ...Orally, rutin may cause gastrointestinal disturbance in some people (313).
Neurologic/CNS ...Orally, rutin may cause headache in some people (313).