Water • SD Alcohol 40-c+SD Alcohol 3-c • Propylene Glycol • Hydolized Glycosaminoglycans (thioglycoran) • Panthenol • Sorbic Acid • Methylparaben • Hyaluronic Acid (H.U.C.P.) • Thurfylnicotinate HCl • THURFYLNICOTINATE Propylparaben • SODIUM HYDROXIDE • Biotin • Fragrance.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
Below is general information about the effectiveness of the known ingredients contained in the product Kevis Extra Strength Hair and Scalp Lotion. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Kevis Extra Strength Hair and Scalp Lotion. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally and appropriately. Biotin has been safely used in doses up to 300 mg daily for up to 6 months. A tolerable upper intake level (UL) has not been established (1900,6243,95662,102965). ...when applied topically as cosmetic products at concentrations of 0.0001% to 0.6% biotin (19344).
POSSIBLY SAFE ...when used intramuscularly and appropriately (8468,111366).
CHILDREN: LIKELY SAFE
when used orally and appropriately.
Biotin has been safely used at adequate intake doses of 5-25 mcg daily for up to 6 months (173,6243,19347,19348,111365). A tolerable upper intake level (UL) has not been established.
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally and appropriately.
Biotin has been safely used at the adequate intake (AI) dose of 30 mcg daily during pregnancy and 35 mcg daily during lactation. It has also been used in supplemental doses of up to 300 mcg daily (6243,7878). A tolerable upper intake level (UL) has not been established.
LIKELY SAFE ...when used orally and appropriately. Supplements standardized to contain hyaluronic acid 70%, in an 80 mg daily dose, have been used daily for up to 3 months with no reports of adverse effects (55742,91779). ...when used topically and appropriately. Hyaluronic acid, in a gel or impregnated gauze, has been safely applied to the skin in clinical trials (7889,7892,104389,108627,108640). ...when eye drop preparations containing up to 0.3% hyaluronic acid are used multiple times per day for up to 3 months (97885,97894,97895,110555).
PREGNANCY:
There is insufficient reliable information available about the safety of hyaluronic acid; avoid using.
LACTATION:
There is insufficient reliable information available about the safety of hyaluronic acid.
It is not known if hyaluronic acid is excreted in breast milk (7890); avoid using.
POSSIBLY SAFE ...when used orally and appropriately. Mesoglycan has been used safely at doses of up to 200 mg daily for up to 18 months (6635,6637,6638,6639,6644,6645,11479,31647,31649,97777)(97778,97779,103263,103264,103265). ...when used intramuscularly under the supervision of a healthcare provider. Mesoglycan has been used with apparent safety at doses of 60 mg daily for up to 5 days and doses up to 30 mg daily for up to 3 weeks (6630,11479,103263). Since mesoglycan products are derived from animals, there are concerns about contamination with diseased animal parts (1825). However, there are no reports of disease transmission to humans due to use of contaminated mesoglycan. There is insufficient reliable information available about the safety of mesoglycan when used topically or intravenously.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally and appropriately. The pantothenic acid derivative calcium pantothenate has a generally recognized as safe (GRAS) status for use in food products (111258). While a tolerable upper intake level (UL) has not been established, pantothenic has been used in doses of 10-20 grams daily with apparent safety (15,6243,111258) ...when applied topically and appropriately, short-term. The Cosmetic Ingredient Review Expert Panel has concluded that pantothenic acid and its derivatives are safe for use in cosmetic products in concentrations up to 5.3% (111258). Gels or ointments containing a derivative of pantothenic acid, dexpanthenol, at concentrations of up to 5%, have been used safely for up to 30 days (67802,67806,67817).
POSSIBLY SAFE ...when applied intranasally and appropriately, short-term. A dexpanthenol nasal spray has been used with apparent safety up to four times daily for 4 weeks (67826). ...when applied in the eyes appropriately, short-term. Dexpanthenol 5% eyedrops have been used with apparent safety for up to 28 days (67783). ...when injected intramuscularly and appropriately, short-term. Intramuscular injections of dexpanthenol 500 mg daily for up to 5 days or 250 mg weekly for up to 6 weeks have been used with apparent safety (67822,111366).
CHILDREN: LIKELY SAFE
when used orally and appropriately (15,6243).
Calcium pantothenate is generally recognized as safe (GRAS) when used as a food additive and in infant formula (111258). However, a tolerable upper intake level (UL) has not been established (15,6243). ...when applied topically and appropriately (67795,105190,111262). Infant products containing pantothenic acid and its derivatives have been used safely in concentrations of up to 5% for infant shampoos and 2.5% for infant lotions and oils. The Cosmetic Ingredient Review Expert Panel has concluded that pantothenic acid and derivatives are safe for use in topical infant products. (111258).
PREGNANCY: LIKELY SAFE
when used orally and appropriately.
The daily adequate intake (AI) during pregnancy is 6 mg (3094).
LACTATION: LIKELY SAFE
when used orally and appropriately.
The daily adequate intake (AI) during lactation is 7 mg (3094).
Below is general information about the interactions of the known ingredients contained in the product Kevis Extra Strength Hair and Scalp Lotion. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, combined use might increase bleeding risk. However, human evidence suggests that mesoglycan has profibrinolytic activity without affecting coagulation (6631,6642,31646). These agents include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
|
Theoretically, combined use might increase bleeding risk (6629). These drugs include alteplase (Activase), anistreplase (Eminase), reteplase (Retevase), streptokinase (Streptase), and urokinase (Abbokinase).
|
Below is general information about the adverse effects of the known ingredients contained in the product Kevis Extra Strength Hair and Scalp Lotion. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally and topically, biotin is generally well tolerated.
Most Common Adverse Effects: None.
Gastrointestinal ...Orally, high-dose biotin has been rarely associated with mild diarrhea. Transient mild diarrhea was reported by 2 patients taking biotin 300 mg daily (95662).
Pulmonary/Respiratory ...In one case report in France, a 76-year-old female frequent traveler developed eosinophilic pleuropericarditis after taking biotin 10 mg and pantothenic acid 300 mg daily for 2 months. She had also been taking trimetazidine for 6 years (3914). Whether eosinophilia in this case was related to biotin, pantothenic acid, other substances, or patient-specific conditions is unknown. There have been no other similar reports.
General
...Orally and topically, hyaluronic acid appears to be well tolerated.
Most Common Adverse Effects:
Topically: Eczema, erythema, itching, wound hemorrhage, wound infection (e.g., erysipelas).
Dermatologic
...The use of needle-free devices to inject hyaluronic acid for cosmetic purposes has been reported to cause serious injury, and in some cases permanent harm, to the skin, lips, and eyes (108613).
Topically, hyaluronic acid application has been reported to cause eczema, erythema, itching, wound hemorrhage, and wound infection (e.g., erysipelas) (108628,108640).
Ocular/Otic ...Ocular pain has been reported rarely in patients using eye drops containing up to 0. 3% hyaluronic acid (97885).
General
...Orally, mesoglycan seems to be well tolerated.
Some adverse effects reported in clinical studies include nausea, vomiting, epigastric pain, dyspepsia, heartburn, headache, diarrhea, and local cutaneous reactions (6629,97778,97779,103265).
However, there is some concern about potential contamination. Mesoglycan is derived from raw animal tissues gathered from slaughterhouses, possibly from sick or diseased animals (6620). Products made from contaminated or diseased organs might present a human health hazard. There is also concern that mesoglycan produced from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be unsafe (1825). However, there are no reports of disease transfer to humans from contaminated mesoglycan.
Dermatologic
...Orally, mesoglycan has been reported to cause local cutaneous reactions (6629,97778).
Subcutaneously, injections of mesoglycan into the scalp were thought to result in edema, redness, and local hair loss in a 32-year-old female (97780).
Gastrointestinal ...Orally, mesoglycan has been reported to cause nausea, vomiting, epigastric pain, dyspepsia, heartburn, and diarrhea (6629,97779,103265).
Neurologic/CNS ...Orally, mesoglycan has been reported to cause headache (6629).
Other
...Mesoglycan is derived from raw animal tissues gathered from slaughterhouses, possibly from sick or diseased animals (6620).
Products made from contaminated or diseased organs might present a human health hazard. However, there are no reports of disease transfer to humans from contaminated mesoglycan.
There is also some concern that mesoglycan that is obtained from cows in countries where bovine spongiform encephalopathy (BSE) has been reported might be unsafe. However, there are no reports of BSE transfer to humans from contaminated mesoglycan (1825).
General
...Orally, pantothenic acid is generally well tolerated.
Topically and intramuscularly, dexpanthenol, a synthetic form of pantothenic acid, seems to be well tolerated.
Most Common Adverse Effects:
Topically: Burning, contact dermatitis, eczema, irritation, and itching related to dexpanthenol.
Cardiovascular ...There is one case of eosinophilic pleuropericardial effusion in a patient taking pantothenic acid 300 mg per day in combination with biotin 10 mg per day for 2 months (3914).
Dermatologic ...Topically, dexpanthenol has been associated with itching, burning, skin irritation, contact dermatitis, and eczema (67779,67781,67788,111258,111262). Three cases of allergic contact dermatitis have been reported (111260,111261).
Gastrointestinal ...Orally, pantothenic acid has been associated with diarrhea (67822,111258).