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Churg-Strauss syndrome

Related Terms

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Background

  • Churg-Strauss syndrome (CSS), also known as allergic granulomatosis, is a rare autoimmune disease that causes vasculitis (blood vessel inflammation), which restricts blood flow to various organs, especially the lungs and skin. The restricted blood flow to these organs can cause temporary or permanent damage.
  • Two scientists, Jacob Churg and Lotte Strauss, first described CSS in 1951 when they reviewed autopsy cases that were previously classified as polyarteritis nodosa (disease that causes inflammation of the arteries). These cases were unusual because they were associated with asthma and extravascular granulomas (clumps of cells that form lumps on the outside of blood vessels), as well as a systemic vasculitis.
  • Individuals who have CSS have an increased level of white blood cells, known as eosinophils. The eosinophils cluster together and release harmful granules, which collect in different regions of the body as inflammatory nodule lesions. This process is called granulomatosis.
  • The age at onset (when symptoms first arise) varies from 15-70 years, with an average of about 38 years. The average age at diagnosis is about 50 years. Researchers estimate that anywhere between 720 and 3,000 Americans have CSS. For unknown reasons, CSS afflicts slightly more men than women, and it can affect individuals of all ages.
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Causes

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Phases and Symptoms of Css

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Diagnosis

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Treatment

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Integrative Therapies

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Prevention

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.