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Stevens-Johnson syndrome

Related Terms

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Background

  • Stevens-Johnson syndrome (SJS) is a type of allergic reaction that usually occurs in response to medications. It is a severe type of erythema multiforme, which is a skin disease characterized by skin eruptions and blisters. SJS is a less severe form of another disease called toxic epidermal necrolysis (TENS).
  • Pediatricians, A.M. Stevens and S.C. Johnson, discovered the disease in 1922 when they treated two young male patients with skin lesions, fever, inflamed mucosa and conjunctivitis (pinkeye).
  • SJS is a systemic disorder that is potentially life threatening, especially if left untreated. About 3-15% of patients with severe SJS die. In severe cases, the lesions can cause significant scarring of the involved organs, which often leads to loss of function of the organ systems. For instance, restriction of the esophagus and of the respiratory tract can occur due to lesions and scaring.
  • SJS typically involves many areas of the body and extensive lesion formation. The lesions can extend to the mucous membranes and affect any organ, including the lungs, eyes, mouth, stomach and intestines. The disease can cause severe damage to the mouth, nose, eye, vagina, urethra, gastrointestinal tract and/or lower respiratory tract.
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Causes

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Adverse Effect Vs. Allergic Reaction

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Symptoms

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Treatment

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Prevention

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Support For Patients

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.