Image for Arabinoxylan
Arabinoxylan

Synonyms/Common Names/Related Substances:

  • Arabinoxylane, Arctostaphylos uva-ursi, AX, BioBran®, cinnaman AX, Cinnamomum cassia, Ganoderma lucidum, Hyphomycetes mycelia, kawaratake mushroom, MGN-3, rice bran, shiitake mushroom, suehirotake mushroom.

Clinical Bottom Line/Effectiveness

Brief Background:

  • Arabinoxylan compound is produced by enzymatically hydrolyzing the outer shell of rice bran using enzymes from Hyphomycetes mycelia mushroom extract. The product called MGN-3 (or BioBran® in Japan) is a hemicellulose complex containing arabinoxylan as a major component (1;2;3;4).
  • This herb has been used to support individuals with low white blood cell counts caused by chemotherapy and to support the immune system of those undergoing treatment for cancer/viral infections, including HIV infected patients.
  • In preliminary human trials, arabinoxylan has been found to improve immune reactions in diabetes and cancer patients. Pre-clinical experiments suggest that MGN-3 may also be of potential value in treating AIDS patients (5). However, there is currently insufficient evidence to support the use of arabinoxylan for any indication. Claims are based on either animal or in vitro studies and strong scientific evidence in humans is lacking. Well-organized clinical trials are needed to determine the efficacy and the safety of arabinoxylan as a proposed preventive/therapeutic agent.
  • Although presented by manufacturers as a generally safe substance without side effects at recommended doses, the United States Food and Drug Administration (FDA) ordered a permanent injunction against the marketing of MGN-3, charging that it has been promoted as a drug treatment for cancer, diabetes and HIV.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.