Image for Belladonna ( L. or its variety Royle ex Lindl)
Belladonna (Atropa belladonna L. or its variety acuminata Royle ex Lindl)

Synonyms/Common Names/Related Substances:

  • Atropa belladonna, atropa belladonna-AE, beladona, belladone, belladonnae herbae pulvis standardisatus, belladonna herbum, Belladonna Homaccord, Belladonna Injeel, Belladonna Injeel Forte, belladonna leaf, belladonna pulvis normatus, belladonnae folium, belladonna radix, belladonne, deadly nightshade, deadly nightshade leaf, devil's cherries, devil's herb, die belladonna, die tollkirsche, divale, dwale, dwayberry, galnebaer, great morel, herba belladonna, hoja de belladonna, naughty man's cherries, poison black cherries, powdered belladonna, Solanaceae (family), solanum mortale, solanum somniferum, stryshon, strygium, tollekirsche, tollkirschenblatter.
  • Combination product examples: Bellergal® (phenobarbital, ergotamine tartrate, and levorotatory alkaloids of belladonna), Bellergal-S® (phenobarbital, ergotamine tartrate, and levorotatory alkaloids of belladonna), Bellergil®, Bel-Phen-Ergot S®, B&O Supprettes®, Cafergot-PB®, Distovagal®, Phenerbel-S®, PMS-Opium & Beladonna®.

Clinical Bottom Line/Effectiveness

Brief Background:

  • Belladonna is an herb that has been used for centuries for a variety of indications, including headache, menstrual symptoms, peptic ulcer disease, inflammation, and motion sickness. Belladonna is known to contain active agents with anticholinergic properties, such as the tropane alkaloids atropine, hyoscine (scopolamine) and hyoscyamine.
  • There are few available studies of belladonna monotherapy for any indication. Most research has evaluated belladonna in combination with other agents such as ergot alkaloids or barbiturates, or in homeopathic (diluted) preparations. Preliminary evidence suggests possible efficacy in combination with barbiturates for the management of symptoms associated with irritable bowel syndrome. However, there is currently insufficient scientific evidence regarding the use of belladonna for this or any other indication.
  • There is extensive literature on the adverse effects and toxicity of belladonna, related principally to its known anticholinergic actions. Common adverse effects include dry mouth, urinary retention, flushing, papillary dilation, constipation, confusion and delirium. Many of these effects may occur at therapeutic doses.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.