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Bifidobacterium longum BB536

Synonyms/Common Names/Related Substances:

  • BAA-999, BB536, BB-536, Bifidobacterium longum NCC3001, bifidus milk, bifidus yogurt, BL999, Morinaga Bifidus®, Morinaga Caldus®, oligodeoxynucleotide (ODN) BL07S.

Clinical Bottom Line/Effectiveness

Brief Background:

  • Bifidobacterium longum BB536 (BB536) is an anaerobic, Gram-positive, non-spore-forming, pleomorphic rod. Bacteria in the Bifidobacterium genus produce lactic and acetic acids as by-products of glucose utilization. BB536 is a type of probiotic bacteria, which, according to secondary sources, was first isolated from the intestinal tract of healthy infants.
  • Supposed health benefits of probiotics in general, as well as BB536 in particular, include regulating intestinal function, protecting against infections, and boosting immunoregulation. Studies in humans suggest that supplementation with BB536 resulted in increased levels of Bifidobacterium and Lactobacillus and decreased levels of harmful bacteria in fecal microflora.
  • At this time, clinical evidence in support of BB536 for allergic disorders is limited mainly to Japanese cedar pollen (JCP); further research on allergic disorders in general is still required. Studies suggest that BB536, along with other probiotics, as part of fermented milk products, improves bowel function and fecal characteristics. Studies investigating the inclusion of BB536 as part of infant formulas suggest that these formulas are not inferior to comparison formulas and may offer small benefit.
  • Further research is required to determine the clinical strength of these potential benefits. According to secondary sources, the European Food Safety Authority suggested that the claimed effects of "bowel regularity," "healthy immune function," and "healthy balance of intestinal bacteria" associated with BB536 lacked a cause-and-effect relationship at this time.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.