Image for Ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome
Ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome

Related Terms

  • Content available for subscribers only.

Background

  • Ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome is a form of ectodermal dysplasia, a group of disorders that affect the outer layer of the developing embryo. This layer, called the embryonic ectoderm, develops into many parts of a baby's body, including the eyes, skin, nails, and hair. In ectodermal dysplasias, these parts of the body do not develop normally.
  • Symptoms of EEC syndrome can range from mild to severe and usually include abnormal or absent fingers and toes, hair defects, cleft palate (an incomplete closure of the roof of the mouth), cleft lip (an abnormal groove in the upper lip beneath the nose), and other facial deformities. In addition, the urinary tract may be affected.
  • Eye problems, such as scarring on the cornea, become more prominent as people with EEC age. The reason for this is unknown. In addition, infections of the eyelids and the lining of the eye are common.
  • There are two types of the disease, each caused by a different genetic mutation. EEC1 is caused by mutations or defects of the TP63 gene. This is the most common form of the disease and is often referred to simply as EEC. EEC3 is caused by mutations of the TP73L gene. A third form of the disease, EEC2, has been proposed, but researchers do not believe that this is a distinct disorder.
  • Further content available for subscribers only.

Risk Factors

  • Content available for subscribers only.

Causes

  • Content available for subscribers only.

Signs and Symptoms

  • Content available for subscribers only.

Types of the Disease

  • Content available for subscribers only.

Diagnosis

  • Content available for subscribers only.

Complications

  • Content available for subscribers only.

Treatment

  • Content available for subscribers only.

Integrative Therapies

  • Content available for subscribers only.

Prevention

  • Content available for subscribers only.

Author Information

  • Content available for subscribers only.

References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

  • Content available for subscribers only.
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.