Synonyms/Common Names/Related Substances:

• 1',5'-O-dicaffeoylquinic acid, 2,6-dimethoxy-4-[(1E)-3,3-dimethoxy-1-propenyl]phenyl beta-D-glucopyranoside, 2,6-dimethoxy-4-(3-hydroxy-propen-1-yl) phenyl-4-O-alpha-L-rhamno-pyranosyl-(1->6)-beta-D-glucopyranoside, 3-(4-O-beta-D-glucopyranosylferuloyl)quinic acid, 3,4-seco-lupane-20(29)-ene-3,28-dioic acid, 3',5'-O-dicaffeoylquinic acid, 4',5'-O-dicaffeoylquinic acid, 5'-O-caffeoylquinic acid and isomers, (7R,8S)-dihydrodehydrodiconiferyl alcohol 4,9'-di-O-beta-D-glucopyranoside, Acanthopanax senticosus, acanthopanaxoside E (3-O-beta-D-glucuronopyranosyl echinocystic acid 28-O-beta-D-glucopyranoside), acanthosides, ADAPT-232, aglycone, alimoxide, alpha-bisabolol, alpha-longipinene, arabinose, Araliaceae (family), Argoeleuter tablets, benzyl-O-alpha-L-rhamno-pyranosyl (1->6)-beta-D-glucopyranoside, beta-sitosterol, caffeic acid, carbohydrate, chlorogenic acid, Circu-Forte^TM, Circulat®, ci wu jia (Chinese), ci wu ju (Chinese), ciwujia (Chinese), ciwujianoside B(1), ciwujianoside C(1), ciwujianoside C(2), ciwujianoside C(3), ciwujianoside C(4), ciwujianoside D(1), ciwujianoside D(2), ciwujianosides, ciwujiatone, complex polysaccharides, copteroside B, devil's bush, devil's shrub, dihydrodehydrodiconiferyl alcohol monopyranose, (E)-anethole, Eleu-kokk®, eleuterozid B, eleuterozid C, eleuterozid D, eleuthera, eleutheran A, eleutheran B, eleutheran C, eleutheran D, eleutheran E, eleutheran F, eleutheran G, eleutherans, eleuthero, eleuthero ginseng, eleutherococc, Eleutherococci radix, Eleutherococcus, eleutheroside B, eleutheroside B1, eleutheroside E, eleutheroside E(1), eleutheroside E(2), eleutherosides, episyringaresinol 4"-O-beta-D-glucopyranoside, erythro-1,2-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanediol, erythro-1-(4-hydroxy-3-methoxy-phenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxy-phenoxy}-1,3-propanediol, essential oil, extractum eleutherococci fluidum, ezoukogi (Japanese), ferulic acid, flavonoids, free phenolic acids, galactose, ginseng, ginsenosides, glucopyranosides, glucose, glucuronic acid, glycans, glycosides, guaia-6,9-dien-4beta-ol, gypsogenin 3-O-beta-D-glucuronopyranoside, Hedera senticosa, hederagenin 3-O-beta-D-glucuronopyranoside 6'-O-methyl ester, hyperin, hyperoside, Hyul-Tong-Ryung, Immuplant tablets, iridoid glycosides, isofraxidin, isofraxidin chiisanoside, isomaltol 3-O-alpha-D-glucopyranoside, Kan Jang®, Kan-Yang, lignans, lycoperodine-l, lyoniresinol, mannose, manyprickle acanthopanax, minerals, monoterpenoids, nicotinamide, oplopanone B, p-coumaric, phenolic acids, p-hydroxybenzoic, phytoestrogen, phytosterols, polyphenols, prickly eleutherococc, protein, protocatechuic acid, rel-5-(1R,5S-dimethyl-3R,4R,8S-trihydroxy-7-oxa-6-oxobicyclo[3,2,1]oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid, rhamnose, rosmarinic acid, Russian root, rutoside, salvadoraside, schisandrin B, senticoside, sesamin, sesquiterpenoids, shigoka, Siberian ginseng wuchaseng extract, silphioside F, spiny eleutherococcus, stigmasterol, sucrose, syringaresinol, syringaresinol diglucoside, syringaresinol-di-O-beta-D-glucoside, syringic acid, syringin, tachioside, Taiga Wurzel, thorny bearer of free berries, thorny pepperbrush, thymidine, thymol, tortoside A, touch me not, triterpene saponins, triterpenoid saponins, untouchable, uronic acid, ussuri, ussurian, vanillic, vitamins, wild pepper, wu jia pi, wuchaseng, wu-jia, wujiaseng, xylose.
• Select combination products: ADAPT-232 (containing Rhodiola rosea, Schisandra chinensis, and Siberian ginseng), AdMax® (dried ethanol-water extracts from roots of Leuzea carthamoides, Rhodiola rosea, Eleutherococcus senticosus, and fruits of Schisandra chinensis), Aidi Injection (cantharis, Astragalus membranaceus, Acanthopanax senticosus root, Panax ginseng), Chisan® (extracts of Rhodiola rosea L., Schisandra chinensis Turcz. Baill., and Eleutherococcus senticosus Maxim.), Circulat® (also called Circu-Forte^TM) (Siberian ginseng root, Rhaponticum carthamoides root, Panax ginseng root, Panax quinquefolius root, Pfaffia paniculata root, Rhodiola rosea root, Echinacea angustifolia root, Echinacea purpurea root, Ganoderma lucidum, Grifola frondosa, Hydrastis canadensis, Petiveria alliacea, Sutherlandia frutescens, Tabebuia avellanedae bark, Uncaria tomentosa root, Angelica sinensis root, Crataegus oxycantha fruit, Croton lechleri bark resin, Gingko biloba leaf, Hydrocotyle asiatica, Ruscus aculeatus root, Vaccinium myrtillus fruit), HT008-1 (composed of Panax ginseng, Siberian ginseng, Angelica sinensis, and Scutellaria baicalensis), Hyul-Tong-Ryung (Salvia miltiorrhiza, chrysanthemum, Acanthopanax senticosus, Cinnamomi ramulus, Eucommiae cortex, licorice, Puerariae radix, Crataegi fructus, Cassiae semen, safflower, peony root, dong quai), ImmunoGuard® (Andrographis paniculata Nees, Eleutherococcus senticosus Maxim., Schizandra chinensis Baill., and Glycyrrhiza glabra L. extracts), Kan Jang® (Echinacea purpurea, Adhatoda vasica, and Eleutherococcus senticosus), Kan-Yang (Andrographis and Siberian ginseng).

Clinical Bottom Line/Effectiveness

Brief Background:

• Siberian ginseng (Eleutherococcus senticosus, Acanthopanax senticosus) is a small, woody shrub in the Araliaceae family native to southeastern Russia, northern China, Korea, and Japan (1). Although it is not related to true ginseng (Panax ginseng), the name Siberian ginseng became popular based on potential properties similar to Panax ginseng. Siberian ginseng is also called "eleuthero" in some products.
• Traditionally, Siberian ginseng has been used as an adaptogen and for increased endurance and memory improvement, as well as for chemoprotection, immunological enhancement, and overall well-being. Overall, there is currently little clinical evidence on the use of Siberian ginseng for these indications.
• There is conflicting evidence from clinical trials regarding the effectiveness of Siberian ginseng for enhanced athletic performance. There is some evidence to suggest increased immune response, according to human research. There is limited human evidence regarding the use of Siberian ginseng to improve cognitive function; treat cancer, diabetic foot ulcers, familial Mediterranean fever, fatigue, genital herpes, neurocirculatory hypotension, menopause, osteoarthritis, osteoporosis, pneumonia, and respiratory tract infections; or improve quality of life. A lack of benefit has been found in the treatment of bipolar disorder. Many human studies have used Siberian ginseng as part of a combination therapy. High-quality studies utilizing Siberian ginseng as a monotherapy are needed.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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