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  • Daio-kanzo-to is a Kampo formula that includes a mixture of rhubarb and licorice. Traditionalists consider it a safe remedy for habitual constipation and other abdominal symptoms.
  • One ingredient, rhubarb, contains known laxative constituents (anthraquinones) similar to those found in approved over-the-counter laxative preparations. The other ingredient, licorice, reduces side effects by protecting mucous membranes. However, there is no meaningful evidence for any such protective effect, nor indication that such a protective effect is needed. Furthermore, licorice presents significant safety risks.
  • The dosage used in clinical trials ranges from 0.5 to 1.5g per day. Adjustments to the dose may be necessary according to the needs of the individual patient.


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Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.