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Liposomal nonviral delivery vehicles

Related Terms

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Background

  • General: Genes are considered the building blocks of life because they provide instructions for all the cells in the body. They are located inside cells and control an organism's development and functions by instructing cells to make new molecules. Genes are passed down from parents to their children.
  • Deoxyribonucleic acid (DNA) is a long thread-like molecule made up of large numbers of nucleotides. The sequence of bases in DNA serves as the carrier of genetic information. A chromosome is a long DNA molecule that carries the hereditary information of an organism.
  • Nucleotides are molecules composed of a nitrogen containing base, a 5-carbon sugar, and one or more phosphate groups. Nitrogen bases are of two types: purines, such as adenine (A) and guanine (G), and pyrimidines, such as cytosine (C) and thymine (T) in DNA. Long strands of nucleotides form nucleic acids. RNA (ribonucleic acid) is a nucleic acid that aids in protein synthesis, which is important for growth and maintenance of the body. RNA is formed under the direction of DNA. Both RNA and DNA help to form amino acids, which are the building blocks of protein.
  • Liposome: A liposome is a man-made small lipid (fat) vesicle that contains water or saline (salt solution) in the center. A vesicle is a small bag or pouch that is surrounded by its own membrane and is found inside the cell. The two-layered walls of the liposomes are made of phospholipids that are similar to the phospholipids found in the cell membrane. Depending on the number of lipid layers, liposomes may be classified as multilamellar vesicles (MLVs), small unilamellar vesicles (SUVs), or large unilamellar vesicles (LUVs). MLVs consist of several lipid layers (up to 14) in an onion-like arrangement. SUVs and LUVs consist of a single lipid layer but differ in the diameter of the liposomes. SUVs are smaller in diameter (25-50nm), whereas LUVs range from 100nm up to 50 micrometers.
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Methods

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Research

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Implications

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Limitations

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Safety

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Future Research

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.