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Noni (Morinda citrifolia)

Synonyms/Common Names/Related Substances:

  • 1,5,15-Tri-O-methylmorindol, 2-methoxy-1,3,6-trihydroxyanthraquinone, 2-O-(beta-D-glucopyranosyl)-1-O-hexanoyl-beta-D-gluropyranose, 2-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-gluropyranose, (-)-3,3'-bisdemethylpinoresinol, (+)-3,3'-bisdemethyltanegool, (+)-3,4,3',4'-tetrahydroxy-9,7'alpha-epoxylignano-7 alpha,9'-lactone, 5,15-dimethylmorindol, 5,15-O-dimethylmorindol, 6alpha-hydroxyadoxoside, 6beta,7beta-epoxy-8-epi-splendoside, 9-epi-6a-methoxy geniposidic acid, Al, alizarin, alkaloids, americanin A, amino acids, anthraquinone, anthraquinone glycoside, asperuloside, asperulosidic acid, atchy (Hindi), beta-sitosterol, beta-sitosterol 3-O-beta-D-glucopyranoside, borreriagenin, cada pilva (Malay), caproic acid, caprylic acid, carotene, catechin, citrifolinin A-1, citrifolinin B epimer a, citrifolinin B epimer b, citrifolinoside, citrifolinoside A, cytidine, deacetylasperuloside, deacetylasperulosidic acid, deacetylasperulosidic acid, dehydromethoxygaertneroside, D-glucose, dilo'k (Pijin), D-mannitol, epicatechin, epi-dihydrocornin, eugenol, flavone glycosides, Indian mulberry, iridoid glycoside, isoscopoletin, kaempferol, kaempferol-3-O-alpha-L-rhamnopyranoysyl-(1-6)-beta-D-glucopyranoside, kura (Fijian), kuti, ladda (Chamorro), L-asperuloside, linoleic acid, lucidin, maddichettoo (Telugu), manganese, manja-pavattay, mengkudu, methyl alpha-D-fructofuranoside, methyl beta-D-fructofuranoside, molagha, Morinda citrifolia, Morinda citrifolia fruit juice concentrate, Morinda citrifolia L., Morinda citrifolia Linn., morindacin, morindone, murier d'Inde (French), najalanun, nakura, narcissoside, nen (Chamorro), niacin, nicotifloroside, nolom, noni berry, noni juice, nonijuice, nono (Cook Islands Maori), nonu (Tongan, Wallisian, Futunian, Niuean, Tokelauan, Tuvaluan), nonu togi (Samoan), noona (Tamil), nordamnacanthal, nowoi (Bislama), octanoic acid, Okinawa noni juice (ONJ), pinoresinol, potassium, proxeronine, quercetin, riro (Tok Pisin), Rubiaceae (family), rubiadin, rubiadin-1-methyl ether, rutin, saponin, scandoside methyl ester, scopoletin, selenium, Tahitian Noni™ Equine Essentials™, Tahitian Noni® Leaf Tea, te non (Gilbertese), terpenoids, ursolic acid, vanillin, vitamin A, vitamin C, yelotri.
  • Select combination products: Tahitian Noni® juice (Morinda citrifolia fruit juice from fruit puree, grape juice concentrate, blueberry juice concentrate, natural flavors), Thrive Adaptogenics, Thrive Adaptogenics Extra, Thrive Adaptogenics Family, Thrive Adaptogenics Max, Thrive Adaptogenics Original (Morinda citrifolia fruit juice from fruit puree, grape juice concentrate, blueberry juice concentrate, natural flavors), Thrive Adaptogenics Pure.

Clinical Bottom Line/Effectiveness

Brief Background:

  • Noni (Morinda citrifolia) is a traditional folk medicinal plant that has been used for over 2,000 years in Polynesia. The Polynesians used noni for its nonmedicinal and medicinal properties, including as a food source, antibacterial, antiviral, antifungal, antitumor, anthelmintic, analgesic, hypotensive, anti-inflammatory, and immunostimulant (1).
  • Noni is a popular supplement. Several clinical trials have explored its medicinal use; however, evidence for most investigated indications in humans is unclear. One methodologically strong clinical trial has shown beneficial effects for the treatment of postoperative nausea (2). There is also some preliminary research suggesting beneficial antioxidant, antilipidemic, and anticancer activity. Although preliminary findings are promising, more high-quality, well-controlled research is warranted in all areas to firmly establish noni's therapeutic effects.
  • Cases of hepatotoxicity in humans have been reported following noni juice consumption (3;4;5;6;7;8). However, upon further investigation, the European Food Safety Authority (EFSA) concluded that compelling evidence is lacking for a causal relationship between noni juice consumption at observed dietary intake levels and adverse liver effects (7;9). Ongoing research into the safety of noni is warranted.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.