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Arabinogalactan
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.

Related Terms

  • AG, alpha-arabinofuranose, Ambrotose®, amphotericin B-arabinogalactan conjugates, Andrographis paniculata, arabinans, arabinogalactan protein, arabinogalactan pectin, arabinose, BCG-CWS, Biophytum petersianum Klotzsch, Biophytum sensitivum (L.) DC, Codium dwarkense, Codium tomentosum, D-arabino-D-galactan, D-galactopyranose, D-galactose, D-glucose, D-rhamnose, Echinacea purpurea, Euonymus sieboldiana seeds, fiber, galactan, galactosamine, galactose, galacturonic acid, GalN, glucuronic acid, Juniperus scopolorum cones, Kaki fruits, L-arabinofuranose, L-arabinose, larch, larch arabinogalactan, larch gum, larch tree, Larix, Larix decidua, Larix kaempferi, Larix laricina, Larix occidentalis, Lch, Mongolian larch, Mongolian larchwood, mountain larch, mugwort pollen, Mycobacterium avium, Mycobacterium bovis BCG, Mycobacterium bovis bacillus Calmette-Guerin, Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium vaccae, neutral arabinogalactan, Nocardia, pectic arabinogalactan, Pinaceae (family), polysaccharide, ragweed pollen, rhamno-arabinogalactans, rhamnose, Silene vulgaris, soluble fiber, stractan, sulfated arabinogalactan, tamarack, Trichilia emetica, ukonan C, Vk2a, Vk100A2a, Vernonia kotschyana, Viscum album, western larch, western tamarack, wild indigo (Baptisia tinctoria), wood gum, wood sugar, xylose.
  • Note: Arabinogalactan is found in many species of plants and is thought to be the primary active compound in the larch tree (Larix spp.). This monograph includes studies on arabinogalactan isolated from other species of plants as well.

Background

  • Arabinogalactans belong to a group of carbohydrates called polysaccharides. When consumed in the diet, arabinogalactan comes from the wood of the larch tree (Larix species) and is approved for use as a dietary fiber by the U.S. Food and Drug Administration (FDA).
  • As a dietary supplement, larch arabinogalactan is used to stimulate the immune system, to fight cancer, and as a prebiotic (a substance used to improve bacteria in the colon). Early study suggests that arabinogalactan may help grow beneficial bacteria in the digestive tract. However, human study has not found that the larch arabinogalactan stimulates the immune system.
  • Future uses of arabinogalactan may include simultaneous use with certain drugs, because arabinogalactan may improve drug effectiveness when used together.
  • Arabinogalactans are found in the cell walls of plants and bacteria and in pollen from mugwort and ragweed that causes allergies. Although these arabinogalactans are also discussed in this monograph, there is no evidence to suggest that dietary arabinogalactans from larch or other plant species have similar effects.

Evidence

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Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

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Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.