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Fermented wheat germ extract
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.

Related Terms

  • 2,6-Dimethoxy-p-benzoquinone, antioxidant biofactor (AOB), Avé©, AVE, Avé®, Avemar® (MSC), Avemar pulvis, catechins, extract of Triticum vulgare germ, extract of wheat germ, fermented wheat germ extract (FWGE), flavanoids, MSC, n-octacosanol, octacosanol, octacosyl alcohol, OncoMar™, phytic acid, rutin, Triticum aestivum germ extract, wheat bran, wheat germ agglutinin.

Background

  • Wheat germ is the nutrient-rich embryo of the wheat kernel, or seed. Wheat germ is high in protein and provides essential vitamins and minerals, such as potassium, iron, B vitamins, zinc, and vitamin E. The wheat germ constitutes approximately 2.5% of the total weight of the wheat kernel.
  • Fermented wheat germ extract (FWGE, Avemar pulvis) was invented by Hungarian biochemist Mate Hidvégi in the early 1990s. In the United States, FWGE is marketed as a dietary supplement, Avé®, by American BioSciences, Inc. (Blauvelt, NY). FWGE is manufactured as Avemar® in Hungary, where it is approved as a "medical nutriment" for cancer patients.
  • Scientific evidence suggests that FWGE may have anticancer effects. FWGE may also improve immune function-associated conditions such as rheumatoid arthritis and systemic lupus erythematosus.

Evidence

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Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

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Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.