Image for Resveratrol
Resveratrol

Synonyms/Common Names/Related Substances:

  • Acetylated derivatives of resveratrol (mono, di, tri), Ban-Ji-Ryun, Banjiryun, Ban-Zhi-Lian, Bauhinia racemosa, Belamcanda chinensis, bergenin, betulin, betulinic acid, bilberries, blueberries, cis-piceid, cis-resveratrol (cis-3,4,5-trihydroxystilbene), Cissus quadrangularis, DMU 212, Elephantorrhiza goetzei, epsilon-Viniferin (a dimer of resveratrol), Erythrophleum lasianthum (Caesalpinioidae, Leguminosae), Eucalyptus sideroxylon, Eucalyptus wandoo, extrait de vin (French), extrait de vin rouge (French), flavanoid, French paradox, gnetin H (a resveratrol analog), Gnetum montanum, grape polyphenols, grape seed proanthycyanidin extract (GSPE), grape skin, heyneanol A (a resveratrol tetramer), hu zhang, hydroxystilbene, hydroxystilbene-1, ko-jo-kon, Liliaceae, Longevinex®, lyophilized grape powder (LGP), mangiferonic acid, mulberries, nonflavanoid polyphenol, nuts, Paeonia lactiflora Pall. (Paeoniaceae), pallidol, parthenocissine A, peanuts, phenolic antioxidant, phytoalexin, phytoalexine, phytoantitoxin, phytoestrogens, phytohormones, phyto-oestrogène (French), phytostilbene, Picea excelsa, piceatannol, pilule de vin, Polygonum cuspidatum, polyphenol, prenylflavanone, protykin, purple grape juice, quadrangularin, red grape skins, red grapes, red wine, red wine polyphenol, RESV, resverol, resveratrol 3-O-beta-D-glucopyranoside, resveratrol disulfate, resveratrol sulfate glucuronide, resveratrol-3-O-glucuronide, resveratrol-3-O-sulfate, resveratrol-4'-O-glucuronide, resveratrol-4'-O-sulfate, resveratrol triphosphate, ResVida®, Revidox®, Reynoutria japonica, RSV, RSVL, Scutellaria barbata D.Don (Lamiaceae), Sophora moorcroftiana Benth., Sophora tomentosa L., spruce, SRT501, stilbene, stilbene derivative resveratrol (RES), stilbene phytoalexin, stilbene polyphenol, stilbenoid, Stilvid®, suffruticosol B (a resveratrol analog), trans-3,4,5'-trihydroxystibene, trans-3,4',5-trihydroxystilbene, transhydroxystilbene, trans-piceid, trans-resveratrol, trans-resveratrol-3-sulfate, tyrphostin, vatdiospyroidol (a resveratrol tetramer), Vaticapauciflora, Vatica rassak (Dipterocarpaceae), vaticanol C (a resveratrol tetramer), vaticaphenol A, Veratrum taliense, viniferin (a resveratrol analog), Vitis vinifera L.

Clinical Bottom Line/Effectiveness

Brief Background:

  • Resveratrol is a naturally occurring hydroxystilbene identified in over 70 plant species, including nuts, grapes, pine trees, and certain vines, as well as in red wine. It is thought to play a role in the prevention of heart disease. A substantial amount of attention has been directed in recent years toward resveratrol for its potential health benefits in humans due to investigation of the "French paradox," the finding that coronary heart disease mortality in France is lower than that observed in other industrialized countries with a similar risk factor profile, due to the frequent consumption of red wine.
  • Resveratrol has been shown in animal and laboratory studies to exhibit antioxidant, anticancer, antiproliferative, antifungal, antiviral, and antibacterial effects. As resveratrol is a constituent of grapes and wines, initial work was focused on linking resveratrol to the beneficial cardiovascular effects of moderate wine intake; however, studies have expanded to examine its effects in a variety of conditions, including various cancers, bacterial infections, fungal infections, viral infections, amyotrophic lateral sclerosis, diabetic polyneuropathy, Alzheimer's disease, Parkinson's disease, chronic obstructive pulmonary disease (COPD), and acute pancreatitis.
  • Although there are several observational studies that correlate the consumption of wine with a decrease in cancer or cardiovascular disease risk (1;2), high-quality human trials supporting the efficacy of resveratrol for any indication are currently lacking in the available literature.
  • According to a report, Dr. D. K. Das has been found guilty of 145 counts of fabrication and falsification of data (3). Dr. Das was a lead researcher in the area of resveratrol, red wine, and cardiovascular health. Some of the studies in this monograph were authored or partially authored by Dr. Das. He is currently associated with scientific controversy, as is the brand of resveratrol Longevinex®.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.